Endocrine Abstracts

Background and aims: The aim was to compare calcium homeostasis indexes in diabetic and non-diabetic patients with or without fractures.Materials and methods: We examined 62 postmenopausal women with type 2 diabetes mellitus (DM), 32 of them had bone fracture within last month. The control group included 54 non-diabetic women, 25 within a group were recently fractured. Groups were comparable in body mass index, age, duration of menopause and calcium inta...

Objective: To study if people with diabetes mellitus (DM) have increased risk of fracture.Methods: The study population consisted of 29 512 people aged 50 years or more. There were 1981 diabetic patients among them. The records of the local trauma clinic for two-year period were analyzed.Results: Women with DM had fewer fractures during two years than women without DM (relative risk 0.43; 95% confidence interval 0.30–0.61). Th...

Objective: To examine association between diabetes properties (type, duration, treatment regiment etc.) and risk of any fracture in diabetic population.Methods: We analyzed local trauma clinic data for 3 sequential years from 2662 diabetic persons who were entered The National Register of diabetes mellitus patients (133 subjects with type 1 diabetes mellitus (T1DM) and 1995 ones with T2DM).Results: Fracture risk was higher in T1DM ...

Objective: Objective to study the hypolipidemic efficacy, hepatoprotective activity, and tolerance of the fixed-dose combination of essential phospholipids with methionine (EPL+M) - Eslidine in the combination therapy with A in patients (pts) with cardiovascular diseases (CVD) and type 2 DM who suffer from hyperlipidemia (HL) in order to optimize their treatment in daily clinical practice.Subjects and methods: The trial enrolled 60 pts (mean age 58.1&#17...

The management of childhood obesity has evolved from hospital led treatment to community-based programmes. This is an audit reviewing the impact of the active children eating smart (ACES) programme for overweight/obese children on the dietetic department in the Royal Hospital for Sick Children; Glasgow. A retrospective audit was carried out of referrals to the dietetic department. Clinic lists for dietetic appointments in 2008 and 2010 were identified and reviewed. In 2008 and...

Background: Childhood-onset GH deficiency (CO-GHD) is perceived to be a cause of low bone density and osteoporosis in adulthood. Data on bone mass and body composition of GH-treated adolescents with CO-GHD at final height are inconsistent.Aims: To compare size/height corrected parameters of bone mass and body composition in adolescents with CO-GHD at final height.Method: Review of CO-GHD treated patients at final height between 200...

Background: GH therapy in adolescents with childhood onset GH deficiency (CO-GHD) is often necessary to prevent adult GHD syndrome and requires a re-evaluation of the GH axis on attainment of final height. Not all individuals with CO-GHD remain GH deficient and re-evaluation is required to confirm or refute adult GHD.Aim: Review the care received by young adults diagnosed with CO-GHD.Design: Retrospective review of young adults wit...

Introduction: Leptin receptors have been identified in many peripheral tissues as well as the CNS including the hippocampus, which is particularly vulnerable in Alzheimer’s disease (AD). Animal data shows that leptin may be implicated in the pathophysiology of AD. The aim of this study was to examine if there is any differences in serum leptin levels between patients with AD and normal controls.Material and methods: Ninety patients with AD and 95 no...

Introduction: Severe hypocalcemia is a life threatening condition, usually symptomatic with cardiovascular and neuromuscular manifestations. Varying clinical presentations and concomitant infections, however, might obscure the right diagnosis, delaying early treatment.Case: A 51-year-old African male presents himself at the emergency department (ED) with complaints of a soar throat, a productive cough and a striking pinched voice. Investigation revealed ...

Introduction: Thyroid storm is a potentially fatal disorder if treatment is not initiated promptly upon assessment at the emergency department (ED).Case: A 20-year-old young woman is referred to the ED with rapid acceleration of complaints of palpitations, fever, diarrhoea and agitation, which had been present since several weeks.On physical examination we saw an uncomfortable, restless woman with a tachycardia of 170/min, and a fe...